SIMULTANEOUS DISTRIBUTION OF T-1824 AND I131-LABELLED HUMAN SERUM ALBUMIN IN MAN 1

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Simultaneous distribution of T-1824 and I131 labelled human serum albumin in man.

The dilution of injected dyes (1-3), especially Evans Blue (T-1824) (4), has gained wide acceptance as a measure of plasma volume (5, 6). Recently, such an interpretation of the "T-1824 space" has been questioned. The challenges are based largely upon discordant volumes of distribution obtained after the simultaneous administration of T-1824 and labelled red blood cells (7-14), or T-1824 and ra...

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Simultaneous measurement in dogs of plasma volume with I131 human albumin and T-1824 with comparisons of their long-term disappearance from the plasma.

vv HEN used for measurement of plasma volume, bovine plasma proteins (I) and dog hemoglobin (2) have the same initial volume distribution as the dye, T-1824, which in the bloodstream combines preferentially with albumin (3). In regard to simultaneous comparisons in dogs of plasma volume measured with T-1824 and human albumin labeled with the 1131 isotope, there are conflicting reports (cf. 4-7)...

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Tissue distribution of I131 labeled human serum albumin following intravenous administration.

Previous studies utilizing I'sl' labeled human serum albumin have revealed that approximately 60 per cent of the total exchangeable albumin of nonedematous subjects is in extravascular locations (1, 2). Following intravenous administration, approximately 4 to 7 days are required for essentially complete equilibration of the labeled albumin between plasma and extravascular tissues (2, 3). In alm...

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Distribution and metabolism of I131 labeled human serum albumin in congestive heart failure with and without proteinuria.

The role of serum albumin in the causation of cardiac edema has been disputed. Starling (1) postulated that circulatory stasis resulting from cardiac insufficiency is responsible for anoxia and increased permeability of the capillary membrane, the consequence of which is the passage of albumin and water into the extravascular spaces. Although Smirk (2) observed evidence of increased capillary p...

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Effect of ACTH on water distribution in man as measured by antipyrine, T 1824 and bromide.

The retention of salt and water by patients receiving ACTH and cortisone is well known (1). If sufficiently marked, rapid weight gain, edema and pulmonary congestion may result. It was considered of interest, therefore, to study the changes in plasma volume, extracellular fluid volume, total body water, and total body chloride occurring in patients receiving adrenocorticotropic hormone. A trans...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1953

ISSN: 0021-9738

DOI: 10.1172/jci102722